This article discusses the alarming rise in sexually transmitted infections (STIs) in the US in 2021, with syphilis rates increasing by 32%. Chlamydia accounted for more than half of the reported cases, and the most concerning increase was in cases of congenital syphilis, which rose by 32% and caused 220 stillbirths and infant deaths. The CDC recommends regular testing for STIs, particularly for pregnant women, in order to prevent further spread of the infection.