Matthew Perry, best known for his role in the hit sitcom "Friends," has died from the acute effects of ketamine, according to an autopsy report released by the Los Angeles Medical Examiner Office. The report states that Perry had been receiving ketamine therapy for depression and anxiety and had been clean from addiction for 19 months prior to his death. First responders went to a home in Pacific Palisades based on a 911 call at 4:07 p.m. about a “water emergency” of an unknown type. Perry's death was ruled accidental with no signs of foul play.